辅助生殖技术研究；内膜癌分子标志物筛选研究；内膜容受性; 生育力保存；严重少弱精子症的辅助生殖治疗和相关产品研发

Assisted reproductive technology；Screening of biomarkers for endometrial cancer；Research on improving endometrial receptivity；Assisted reproductive therapy and related product development for Oligoasthenozoospermia

行政与学术任职：

bat365中文官方网站附属同济医院科研处副处长（主持工作）

bat365中文官方网站附属同济医院妇产科/辅助生殖中心教授

学术任职：

全国生育力保存与修复专委会委员

上海市医学会生殖医学专业委员会委员

上海市中西医结合生殖内分泌学会委员

Administrative position:

Director of Scientific Research Department of TONGJI HOSPITAL OF TONGJI UNIVERSITY

Academic position:

Member of CHINA MATERNAL AND CHILD HEALTH ASSOCIATION

Member of the Shanghai Reproductive Medicine Branch

Member of Shanghai Association of Chinese Integrative Medicine

主要研究辅助生殖技术、内膜癌分子标志物筛选、内膜容受性改善等，作为通讯作者在Cancer Research、Cancer letters、Oncogene、Fertility and Sterility、Modern pathology、Eur J Med Chem等杂志发表SCI论文70篇。

欢迎各位硕、博生报考。

Our research interesting focus on ART and endometrial pathological mechanism.

Welcome to join Zhang lab！

部分论著：

Ning CC, Xie B, Chen X, Zhang Z**, Feng Y, Infiltrating Macrophages Induce ERa Expression through an IL 17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen. Cancer Research. 2016 Mar 15;76(6):1354-66.

Bai minzhu, Yang linlin, Liao Hong, Feng youji, Zheng wenxin, Zhang Z**; Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism. Oncogene. 2018 Oct; 37(42):5666-5681

Chen J, Bai M, Ning C, Xie B, Zhang J, Liao H, Xiong J, Tao X, Yan D, Xi X, Chen X, Yu Y, Bast RC, Zhang Z**, Feng Y, Zheng W. Gankyrin Facilitates Follicle Stimulating Hormone-Driven Ovarian Cancer Cell Proliferation through the PI3K/AKT/HIF-1α/Cyclin D1 Pathway. Oncogene. 2016 May 12; 35(19):2506-17

Sun Di, Zuoshu Qin, Yuan Xu, Qimeng Xiao, Yiqing Xu, Mingzhu Bai, Wen Li, Yong Liu, Wenxin Zheng, Zhenbo Zhang**. The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem differentiation. Cancer Letters. 2022 Feb 1;526: 311-321.

Zhang Z*, Jia L, Feng Y, Zheng W. Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer. Cancer Lett. 2009 Jun 8; 278(1):56-64.

Zhang Z*, Zhou D, Lai Y, Liu Y, Tao X, Wang Q, Zhao G, Gu H, Liao H, Zhu Y, Xi X, Feng Y.. Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways. Cancer Lett. 2012 Jun 1; 319(1):89-97.

Zhang J, Yang Y, Zhang Z**, He Y, Liu Z, Yu Y, Wu S, Cai B, Feng Y. Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway. Cancer Lett. 2013 Oct 10; 339 (2):279-87.

Chen X, Zhang Z*, Feng Y, Fadare O, Wang J, Ai Z, Jin H, Gu C, Zheng W, et al. Aberrant survivin expression in endometrial hyperplasia: another mechanism of progestin resistance. Mod Pathol. 2009 May; 22(5):699-708.

Qimeng Xiao, Yuanhao Liu, Guizhi Jiang, Yuan Liu, Yan Huang, Wukun Liu, Zhenbo Zhang**. Heteroleptic Gold(I)-bisNHC Complex with Excellent Activity in Vitro, ex Vivo and in Vivo against Endometrial Cancer. Eur J Med Chem. 2022, Accept.

Chen W, Bai MZ, Yang Y, Sun D, Wu S, Sun J, Wu Y, Feng Y, Wei Y, Chen Z, Zhang Z**. ART strategies in Klinefelter syndrome. J Assist Reprod Genet. 2020 Sep;37(9):2053-2079. (介绍了克氏综合症的辅助生殖治疗规范)

Jian sun, Wei Chen, Minzhu Bai, Zhenbo Zhang**, Yu Wu, Zheng Li. Successful Pregnancy Derived from Cryopreserved Rare Human Spermatozoa with Novel Cryo-piece through Intracytoplasmic Sperm Injection. Andrology. 2017 Jul;5(4):832-837. (Q1区，向国际同行介绍了我们自创具有自主知识产权的单精子冻存技术专利和临床应用效果，解决极限患者精子数量少于5条辅助生殖治疗难题，发明专利号：ZL 2016 1 0396509.1)