卵巢癌发生的分子机制，早期特异标志分子的发掘以及子宫内膜癌的分子分型及其发病机制的研究；妊娠期胎盘相关疾病的发病机制及早期诊断。
Molecular mechanism of ovarian cancer, discovery of early specific markers, molecular typing and pathogenesis of endometrial cancer; Pathogenesis and early diagnosis of placenta-related diseases during pregnancy.

中国阴道镜与宫颈病理学委员会委员，上海市医师协会会员。
Member of Chinese Committee on Colposcopy and Cervical Pathology and Member of Shanghai Medical Association.

主持及参与科研项目：1. 上海市卫生与健康委员会面上项目 (编号：201840308) “血清外泌体蛋白在卵巢癌液体诊断中的筛选及鉴定” 项目负责人，2019.01-2021.12, RMB 10,000

2. The main participants of the National Natural Science Foundation of China (No. 81771591) "Study on the effect and mechanism of 9-tetrahydrocannabinol on placental development", 2018.01-2021.12, RMB 700,00

3. National Natural Science Foundation of China (No. 81270703), "Effects of Long-term Hypoxia on Placental Angiogenesis and Molecular Mechanisms" Project main participants, 2013.01-2016.12, RMB 700,000

4. National Natural Science Foundation of China Youth Project (No. 81201599), "HDAC2 Polarization Regulation Mechanisms of Macrophages and Their Role in Immune Escape from Cervical Cancer", major participants, 2013.01-2016.12, RMB 200,000

5. National Natural Science Foundation Youth Project (No. 81100429), "Effects of aromatic hydrocarbon receptor-mediated dioxin-like environmental pollutant TCDD on placental vascular development and its molecular mechanism." Project participants, 2012.01-2014.12, RMB 220,000

6. Shanghai Natural Science Foundation (No. 11ZR1428700), "The Role of Aromatic Hydrocarbon Receptor (AhR) in Placental Angiogenesis". Main Participants, 2011.03-2014.04, RMB 100,000

7. Head of the Youth Project of Shanghai Health and Health Commission (No. 2007 Y48), "Isolation, Culture and Identification of Ovarian Epithelial Cancer Stem Cells", 2008.01-2011.12, RMB 25,000

论文发表：

第一作者论文：1. Yao JL, He QZ(Co-first author), Liu M, Chang XW, Wu JT, Duan T*, Wang K*. Effects of THC on human amniotic epithelial cell proliferation and migration. Toxicology. 2018;394: 19-26.

2. He QZ, Luo XZ, Wang K, Zhou Q, Ao H, Yang Y, Li SX, Li Y, Zhu HT, DuanT .Isolation and characterization of cancer stem cells from high-grade serous ovarian carcinomas.Cell Physiol Biochem. 2014, 33(1):173-84

3. He QZ, Luo XZ, Zhou Q, Wang K, Li SX, Li Y, Zhu HT, Duan T.Expression of nestin in ovarian serous cancer and its clinicopathologic significance. Eur Rev Med Pharmacol Sci. 2013 ,17(21):2896-901.

通讯作者论文：1.郝克红，贺其志。子宫内膜息肉超声与病理诊断结果比较。bat365中文官方网站学报(医学版），2019，40（2）：244-247.

2. 夏银娣,朱慧庭,王庆萍, 蒋蓓琦, 贺其志. 乳腺癌患者Ki67指数的临床意义. 中国医刊，2017, 52(1)：68-71.

3. Luo XZ , He QZ*, Wang K. Expression of Toll-like receptor 4 in ovarian serous adenocarcinoma and correlation with clinical stage and pathological grade. Eur Rev Med Pharmacol Sci. 2015, 8(8):14323-14327.

既非第一作者又非通讯作者论文

1. Chang X, Li H, Li Y, He Q, Yao J, Duan T*, Wang K*. RhoA/MLC signaling pathway is involved in Δ⁹-tetrahydrocannabinol-impaired placental angiogenesis. Toxicol Lett. 2018; 285:148-155.

2. Fang Y, Ye L, Zhang T, He QZ, Zhu JL.High expression of herpesvirus entry mediator (HVEM) in ovarian serous adenocarcinoma tissue. J BUON. 2017,22(1):80-86.

3. Chang X, Bian Y, He Q, Yao J, Zhu J, Wu J, Wang K*, Duan T*. Suppression of STAT3 Signaling by Δ9-Tetrahydrocannabinol (THC) Induces Trophoblast Dysfunction. Cell Physiol Biochem. 2017 ;42:537-550.

4. Zhou J, Ni XT, Huang XJ, Yao JL, He QZ, Wang K*, Duan T*. Potential role of hyperglycemia in fetoplacental endothelial dysfunction in gestational diabetes mellitus. Cell Physiol Biochem. 2016;39(4):1317-28.

5. Wu Y, Chen X, Chang X, Huang YJ, Bao S, He Q, Li Y, Zheng J, Duan T*, Wang K*. Potential Involvement of Placental AhR in Unexplained Recurrent Spontaneous Abortion. Reprod Toxicol. 2016;59:45-52.

6.Ning C, Xie B, Zhang L, Li C, Shan W, Yang B, Luo X, Gu C, He Q, Jin H, Chen X, Zhang Z, Feng Y. Infiltrating macrophages induce ERα expression through an IL-17A-mediated epigenetic mechanism to sensitize endometrial cancer cells to estrogen. Cancer Res. 2016 Jan 7. pii: canres.1260.2015. [Epub ahead of print]

7.Fu Y, Shao ZM, He QZ, Jiang BQ, Wu Y, Zhuang ZG.Hsa-miR-206 represses the proliferation and invasion of breast cancer cells by targeting Cx43.Eur Rev Med Pharmacol Sci. 2015;19(11):2091-104.

8. Li Y, Yang Y, He QZ, Li SX, Lu HJ.Frozen section of uterine curetting in excluding the possibility of ectopic pregnancy--a clinicopathologic study of 715 cases. ClinExpObstet Gynecol. 2014;41(4):419-22

9. Wu Y, Chen X, Zhou Q, He Q, Kang J, Zheng J, Wang K, Duan T. ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR. PLoS One.2014 , 9(1):e86549

10. Tan YZ, Wang HJ, Zhang MH, Quan Z, Li T, He QZ. CD34+ VEGFR-3+ progenitor cells have a potential to differentiate towards lymphatic endothelial cells. J Cell Mol Med. 2014 , 18(3):422-33