长期从事泌尿系肿瘤的微创及综合治疗，主攻前列腺疾病包括前列腺增生和前列腺癌的基础和临床研究工作，主要研究方向：前列腺癌侵袭迁移及血管新生的分子机制。主持江西省自然科学基金、上海市卫计委及浦东新区卫计委科研项目各一项，参与国家国际科技合作基金、国家自然科学基金及浦东新区科委课题多项。在国内外专业期刊上发表论文20余篇，其中SCI文章10余篇。
Our main research
domain are basic and clinical studies of prostatic diseases, including
prostatic hyperplasia and prostate cancer, especially the molecular mechanism
of metastasis and angiogenesis of prostate cancer. We have one Natural Science
Fund of Jiangxi, one key project of the Shanghai Municipal Health Planning
Commission and several other research project. More than 20 papers have been
published in professional journals, including more than 10 articles in international
peer-reviewed journals.
Bibliography：
1. Chen W, Delongchamps N, Mao K, Beuvon Fdr,
Peyromaure Ml, Liu Z, Dinh‑Xuan A: High RhoA expression at the tumor front in
clinically localized prostate cancer and association with poor tumor
differentiation. Oncology letters 2016, 11(2):1375-1381.
2. Chen W, Mao K, Hua-Huy T, Bei Y, Liu Z,
Dinh-Xuan AT: Fasudil inhibits prostate cancer-induced angiogenesis in vitro.
Oncology reports 2014, 32(6):2795-2802.
3. Chen W, Mao K, Liu Z, Dinh-Xuan AT: The
role of the RhoA/Rho kinase pathway in angiogenesis and its potential value in
prostate cancer. Oncology letters 2014, 8(5):1907-1911.
4. Zhou SK, Chen WH, Shi ZD, Wang SP, Li L,
Wen XF, Wang YM: Silencing the expression of Cbl-b enhances the immune
activation of T lymphocytes against RM-1 prostate cancer cells in vitro.
Journal of the Chinese Medical Association : JCMA 2014, 77(12):630-636.
5. Shi ZD, Li XF, Hao L, Zhao Y, Wang YX,
Dong BZ, Chen WH, Zhang ZG, Wang YM, Fu Q et al: Cbl-b gene silencing in
splenic T lymphocytes as a therapeutic strategy to target the prostate cancer
RM-1 cell tumors in immune competent mice. European review for medical and
pharmacological sciences 2014, 18(24):3819-3830.
6. Bei Y, Hua-Huy T, Duong-Quy S, Nguyen VH,
Chen W, Nicco C, Batteux F, Dinh-Xuan AT: Long-term treatment with fasudil
improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via
inhibition of Smad2/3 phosphorylation. Pulmonary pharmacology &
therapeutics 2013, 26(6):635-643.
Le-Dong
NN, Duong-Quy S, Bei Y, Hua-Huy T, Chen W, Dinh-Xuan AT: Measuring exhaled
nitric oxide in animal models: methods and clinical implications. Journal of
breath research 2012, 6(4):047001.
